Anti-TMEM119 antibody [28-3] - Microglial marker,Abcam,AB209064

Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-FoFr, IHC-Fr and IHC-P Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) was first used in a scientific publication in 2016 and has been cited over 139 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has been confirmed by IHC testing in TMEM119 knockout Mouse brain cells. Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) has 20 independent reviews from customers. Anti-TMEM119 antibody [28-3] - Microglial marker (ab209064) specifically detects TMEM119 (UniProt ID: Q4V9L6; Molecular weight: 27kDa) and is sold in a convenient trial size to enable initial testing (10 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone 28-3 - ab234501 . TMEM119 is a marker for microglia, the resident immune cells of the brain. In Alzheimer's disease (AD) research, TMEM119 is used to differentiate microglia from other brain-resident cells and infiltrating macrophages. Altered TMEM119 expression in AD brains reflects microglial activation and neuroinflammation, making it a valuable tool for studying the immune response and pathology in Alzheimer's disease. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents .

Host

Rabbit

Reactivity

Mouse

Application

IHC-Fr, IHC-P, IHC-FoFr

Platform ID

BAB433424943

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TMEM119 antibody [28-3] - Microglial marker
Cat. No.AB209064
HostRabbit
IsotypeIgG
ReactivityMouse
ApplicationIHC-Fr, IHC-P, IHC-FoFr
ClonalityMonoclonal
Clone Number28-3
Concentration0.154 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an important role in bone formation and normal bone mineralization (PubMed : 20025746, PubMed : 22416756, PubMed : 26207632). Promotes the differentiation of myoblasts into osteoblasts (PubMed : 20025746, PubMed : 22416756, PubMed : 22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed : 21239498, PubMed : 22579779). Up-regulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed : 24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed : 26207632). See full target information Tmem119

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