Anti-TMEM119 antibody - C-terminal - Microglial marker,Abcam,AB185333

Product Specifications Anti-TMEM119 antibody - C-terminal (ab185333) is a rabbit polyclonal antibody and is validated for use in IHC-P in human samples. Anti-TMEM119 antibody - C-terminal (ab185333) specifically detects TMEM119 (UniProt ID: Q4V9L6; Molecular weight: 26kDa) and is sold in 100µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-TMEM119 antibody - C-terminal (ab185333) has high sensitivity and specificity. Anti-TMEM119 antibody - C-terminal (ab185333) has been cited over 40 times in peer reviewed journals and is trusted by the scientific community. Anti-TMEM119 antibody - C-terminal (ab185333) has 7 independent reviews from customers.

Host

Rabbit

Reactivity

Human

Application

IHC-P

Platform ID

BAB058437437

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TMEM119 antibody - C-terminal - Microglial marker
Cat. No.AB185333
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P
ClonalityPolyclonal
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TMEM119 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed : 20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). See full target information TMEM119

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