Anti-TMEM41B antibody [EPR28149-41] - BSA and Azide free,Abcam,AB314764
ab314764 is the carrier-free version of ab314763 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human
Application
IP, WB
Platform ID
BAB871393468
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed : 33850023, PubMed : 33929485, PubMed : 34015269). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed : 33850023, PubMed : 33929485, PubMed : 34015269). Required for autophagosome formation : participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed : 30093494, PubMed : 30126924, PubMed : 30933966, PubMed : 33850023, PubMed : 33929485, PubMed : 34015269, PubMed : 34043740). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed : 33850023). Required for normal motor neuron development (By similarity).. (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed : 33338421, PubMed : 33382968). Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed : 33382968). See full target information TMEM41B
Category Paths
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