Anti-TNF Receptor I antibody,Abcam,AB19139

What is this antibody validated in? Anti-TNF Receptor I antibody (ab19139) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples. What is the molecular weight of TNF Receptor I? Anti-TNF Receptor I (ab19139) specifically detects a band for TNF Receptor I (UniProt: P25118) at a molecular weight of 50kDa. Trusted by the scientific community Anti-TNF Receptor I (ab19139) was first used in a scientific publication in 2005 and has been cited over 120 times in peer-reviewed journals. Reviewed by scientists Anti-TNF Receptor I (ab19139) has over 15 independent reviews from customers.

Host

Rabbit

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB122218072

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TNF Receptor I antibody
Cat. No.AB19139
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Mouse Tnfrsf1a aa 1-50. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). See full target information Tnfrsf1a

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