Anti-TNFSF18/GITRL antibody [YGL386],Abcam,AB245694

Target data Cytokine that binds to TNFRSF18/AITR/GITR (PubMed : 14521928, PubMed : 14647196). Regulates T-cell responses (PubMed : 14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed : 14608036, PubMed : 15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed : 14521928, PubMed : 14647196, PubMed : 18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed : 23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed : 24107315). See full target information Tnfsf18