Anti-TNPO3 antibody [3152C2a],Abcam,AB54353

Target data Importin, which transports target proteins into the nucleus (PubMed : 10366588, PubMed : 10713112, PubMed : 11517331, PubMed : 12628928, PubMed : 24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed : 10366588, PubMed : 10713112, PubMed : 11517331, PubMed : 12628928, PubMed : 24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed : 30916345, PubMed : 31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed : 23878195, PubMed : 24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed : 23878195, PubMed : 24449914).. (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed : 18722123, PubMed : 21901095, PubMed : 22398280, PubMed : 29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed : 21901095, PubMed : 22398280). See full target information TNPO3