Anti-TOM70 antibody,Abcam,AB251925

Host

Rabbit

Reactivity

Human

Application

IHC-P, WB, ICC/IF

Platform ID

BAB497805290

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-TOM70 antibody
Cat. No.AB251925
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, WB, ICC/IF
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TOMM70 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed : 12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed : 12526792, PubMed : 35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed : 20628368, PubMed : 25609812, PubMed : 32728199). Upon Sendai virus infection, recruits HSP90AA1 : IRF3 : BAX in mitochondrion and the complex induces apoptosis (PubMed : 25609812). See full target information TOMM70

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.