Anti-TOM70 antibody [EPR26576-162] - BSA and Azide free,Abcam,AB290002

ab290002 is the carrier-free version of ab289977 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, WB, IHC-P, Flow Cyt (Intra), IP

Platform ID

BAB435324031

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TOM70 antibody [EPR26576-162] - BSA and Azide free
Cat. No.AB290002
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, WB, IHC-P, Flow Cyt (Intra), IP
ClonalityMonoclonal
Clone NumberEPR26576-162
Concentration1.044 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed : 12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed : 12526792, PubMed : 35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed : 20628368, PubMed : 25609812, PubMed : 32728199). Upon Sendai virus infection, recruits HSP90AA1 : IRF3 : BAX in mitochondrion and the complex induces apoptosis (PubMed : 25609812). See full target information TOMM70

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