Anti-TRC8 antibody - C-terminal,Abcam,AB189173

Target data E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed : 10500182, PubMed : 12032852, PubMed : 17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed : 19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed : 19706601, PubMed : 20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed : 22143767, PubMed : 23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed : 22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed : 23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed : 22143767, PubMed : 23223569). Required for INSIG1 ubiquitination (PubMed : 20068067). May be required for EIF3 complex ubiquitination (PubMed : 20068067). See full target information RNF139