Anti-TRPV4 antibody [RM1062] - BSA and Azide free,Abcam,AB314455
ab314455 is the carrier-free version of ab314454 . What are recombinant multiclonals? Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including: - The sensitivity of polyclonal antibodies by recognising multiple epitopes - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production View our range of recombinant multiclonal antibodies . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Application
IHC-Fr, IP, IHC-P, WB
Platform ID
BAB752927830
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed : 16293632, PubMed : 18695040, PubMed : 18826956, PubMed : 22526352, PubMed : 23136043, PubMed : 29899501). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed : 18695040, PubMed : 18826956, PubMed : 29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed : 16293632, PubMed : 18695040, PubMed : 18826956, PubMed : 20037586, PubMed : 21964574, PubMed : 25256292). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed : 12724311, PubMed : 18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed : 19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed : 19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed : 18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed : 26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed : 29899501). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity).. Isoform 1. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.. Isoform 5. Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.. Isoform 2. Lacks channel activity, due to impaired oligomerization and intracellular retention.. Isoform 4. Lacks channel activity, due to impaired oligomerization and intracellular retention.. Isoform 6. Lacks channel activity, due to impaired oligomerization and intracellular retention.. (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X.. (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X.. (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X. See full target information TRPV4
Category Paths
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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