Anti-TSG101 antibody [EPR7130(B)],Abcam,AB125011
Anti-TSG101 antibody [EPR7130(B)] (ab125011) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P and WB. Anti-TSG101 antibody [EPR7130(B)] (ab125011) was first used in a scientific publication in 2014 and has been cited over 603 times in peer reviewed journals. It's performance in Western Blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-TSG101 antibody [EPR7130(B)] (ab125011) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-TSG101 antibody [EPR7130(B)] (ab125011) has 10 independent reviews from customers. Anti-TSG101 antibody [EPR7130(B)] (ab125011) specifically detects TSG101 (UniProt ID: Q99816; Molecular weight: 44kDa) and is sold in a convenient trial size to enable initial testing (10 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR7130(B) - ab207567 . Antibody clone EPR7130(B) is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, PE, Alexa Fluor ® 555, APC ( ab207663 , ab207664 , ab209927 , ab214404 , ab316299 ). Tumor Susceptibility Gene 101 (TSG101) is involved in the endosomal sorting complex required for transport (ESCRT) pathway, which is crucial for cellular processes like vesicle trafficking and degradation. Alterations in TSG101 expression are linked to various cancers, including breast cancer and glioblastoma, where it can act as both a tumor suppressor and an oncoprotein depending on the context. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, Flow Cyt (Intra), ICC/IF, WB
Platform ID
BAB253277662
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed : 22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed : 22315426). See full target information Tumor susceptibility gene 101 protein
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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