Anti-TTF1/Nkx2-1 antibody [EP1584Y],Abcam,AB76013

Anti-TTF1/Nkx2-1 antibody [EP1584Y] (ab76013) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P and WB. Anti-TTF1/Nkx2-1 antibody [EP1584Y] (ab76013) was first used in a scientific publication in 2004 and has been cited over 175 times in peer reviewed journals. It's performance in IHC in mouse and human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-TTF1/Nkx2-1 antibody [EP1584Y] (ab76013) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-TTF1/Nkx2-1 antibody [EP1584Y] (ab76013) has 16 independent reviews from customers. Anti-TTF1/Nkx2-1 antibody [EP1584Y] (ab76013) specifically detects TTF1/Nkx2-1 (UniProt ID: P43699; Molecular weight: 39kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1584Y - ab216648 . Antibody clone EP1584Y is also available pre-conjugated to a variety of labels for your convenience - Biotin ( ab314937 ). Top cited antibody in the market for this target with >250 citations. TTF1, also known as NKX2-1, is a crucial thyroid transcription factor involved in the development of the lung, thyroid and brain. It serves as a key marker in diagnosing lung cancer and is implicated in brain-lung-thyroid syndrome. Abnormal TTF1 expression is linked to various diseases, including non-small cell lung cancer and congenital hypothyroidism. Monitoring TTF1 levels can provide valuable insights into disease mechanisms and therapeutic targets. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

IHC-P, WB

Platform ID

BAB941471079

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TTF1/Nkx2-1 antibody [EP1584Y]
Cat. No.AB76013
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIHC-P, WB
ClonalityMonoclonal
Clone NumberEP1584Y
Concentration0.155 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). See full target information NKX2-1

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