Anti-TTF1/Nkx2-1 antibody [SP141],Abcam,AB227652

What is this antibody validated in? Anti-TTF1/Nkx2-1 antibody [SP141] (ab227652) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. Collaboration Anti-TTF1/Nkx2-1 [SP141] (ab227652) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Other related products We have a range of other formats of antibody clone [SP141] also available for your convenience: ab227652, Carrier free - ab242428 , ab279633, Alexa Fluor® 488 - ab320462 , Alexa Fluor® 647 - ab320463 , Alexa Fluor® 555 - ab320464 , Alexa Fluor® 594 - ab320465 , PE - ab320466 , APC - ab320467 , Alexa Fluor® 750 - ab321437

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, IHC-P, Flow Cyt (Intra), IHC-Fr

Platform ID

BAB754027302

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-TTF1/Nkx2-1 antibody [SP141]
Cat. No.AB227652
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, IHC-P, Flow Cyt (Intra), IHC-Fr
ClonalityMonoclonal
Clone NumberSP141
Concentration0.129 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.6 Preservative: 0.099% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). See full target information NKX2-1

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