Anti-TXNIP antibody [EPR14774],Abcam,AB188865
What is this antibody validated in? Anti-TXNIP antibody [EPR14774] (ab188865) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples. What is the molecular weight of TXNIP? Anti-TXNIP [EPR14774] (ab188865) specifically detects a band for TXNIP (UniProt: Q9H3M7) at a molecular weight of 44kDa. Trusted by the scientific community Anti-TXNIP [EPR14774] (ab188865) was first used in a scientific publication in 2014 and has been cited over 90 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-TXNIP antibody [EPR14774] (ab188865) has been confirmed by Western blot testing in TXNIP Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR14774] also available for your convenience: ab188865, ab210826 , Carrier free - ab215366 , Carrier free - ab232330 , PE - ab318336 , APC - ab318439 , Alexa Fluor® 488 - ab318542 , Alexa Fluor® 647 - ab318645 , Alexa Fluor® 594 - ab318748 , Alexa Fluor® 555 - ab318848 , Alexa Fluor® 750 - ab321310 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB
Platform ID
BAB192295683
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed : 17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed : 12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed : 18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed : 21460850). See full target information TXNIP
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