Anti-TXNIP antibody [EPR14774] - Mouse IgG2b (Chimeric),Abcam,AB210826
This mouse monoclonal chimeric antibody has been engineered from a RabMAb parent antibody ( ab188865 ). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended.
Host
Mouse
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB, Flow Cyt (Intra), ICC/IF
Platform ID
BAB817308177
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed : 17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed : 12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed : 18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed : 21460850). See full target information TXNIP
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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