Anti-Tau antibody [EP2456Y],Abcam,AB76128

Product Specifications Anti-Tau antibody [EP2456Y] (ab76128) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, WB in human, mouse, rat samples. Anti-Tau antibody [EP2456Y] (ab76128) specifically detects Tau (UniProt ID: P10636; Molecular weight: 79kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Tau antibody [EP2456Y] (ab76128) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Tau antibody [EP2456Y] (ab76128) has been cited over 22 times in peer reviewed journals and is trusted by the scientific community. Related Products Antibody clone EP2456Y is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, PE, Alexa Fluor® 555 ( ab206060 , ab210985 , ab215290 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

Flow Cyt (Intra), IHC-P, ICC/IF, WB

Platform ID

BAB362647668

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tau antibody [EP2456Y]
Cat. No.AB76128
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationFlow Cyt (Intra), IHC-P, ICC/IF, WB
ClonalityMonoclonal
Clone NumberEP2456Y
Concentration0.529 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed : 21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed : 21985311, PubMed : 32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. See full target information MAPT Additional targets MAPT

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