Anti-Tau (phospho S422) antibody [EPR2866],Abcam,AB79415

What is this antibody validated in? Anti-Tau (phospho S422) antibody [EPR2866] (ab79415) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Dot Blot in Human samples. What is the molecular weight of Tau? Anti-Tau (phospho S422) [EPR2866] (ab79415) specifically detects a band for Tau (UniProt: P10636) at a molecular weight of 79kDa. Trusted by the scientific community Anti-Tau (phospho S422) [EPR2866] (ab79415) was first used in a scientific publication in 2009 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR2866] also available for your convenience: ab79415, Carrier free - ab196365 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

Agg, Dot, WB

Platform ID

BAB238084958

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tau (phospho S422) antibody [EPR2866]
Cat. No.AB79415
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationAgg, Dot, WB
ClonalityMonoclonal
Clone NumberEPR2866
Concentration0.066 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% Ethylenediaminetetraacetic acid, disodium, dihydrate
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed : 21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed : 21985311, PubMed : 32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. See full target information MAPT phospho S422 Additional targets MAPT phospho S422

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