Anti-Tet2 antibody,Abcam,AB124297
What is this antibody validated in? Anti-Tet2 antibody (ab124297) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. What is the molecular weight of Tet2? Anti-Tet2 (ab124297) specifically detects a band for Tet2 (UniProt: Q4JK59) at a molecular weight of 223kDa. Trusted by the scientific community Anti-Tet2 (ab124297) was first used in a scientific publication in 2013 and has been cited over 30 times in peer-reviewed journals. Reviewed by scientists Anti-Tet2 (ab124297) has over 10 independent reviews from customers. Specificity confirmed The specificity of Anti-Tet2 antibody (ab124297) has been confirmed by Western blot testing in Tet2 Knockout Mouse ES samples.
Host
Rabbit
Reactivity
Mouse
Application
WB, ICC/IF
Platform ID
BAB740433830
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. See full target information Tet2
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
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