Anti-Thymidine Kinase 1/TK1 antibody [C1],Abcam,AB239509

Host

Mouse

Reactivity

Human

Application

IHC-P, WB, ICC/IF

Platform ID

BAB617570304

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Thymidine Kinase 1/TK1 antibody [C1]
Cat. No.AB239509
HostMouse
IsotypeIgG2b
ReactivityHuman
ApplicationIHC-P, WB, ICC/IF
ClonalityMonoclonal
Clone NumberC1
Concentration0.41 - 1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human TK1.
PurityAffinity purification Protein A/G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed : 9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed : 22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed : 22385435). See full target information TK1

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