Anti-Thyroglobulin antibody [1D4],Abcam,AB16853

Host

Mouse

Reactivity

Human

Application

IHC-P

Platform ID

BAB555288949

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Thyroglobulin antibody [1D4]
Cat. No.AB16853
HostMouse
IsotypeIgG2a
ReactivityHuman
ApplicationIHC-P
ClonalityMonoclonal
Clone Number1D4
ImmunogenFull Length Protein corresponding to Human Thyroglobulin. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: Tissue culture supernatant, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed : 17532758, PubMed : 32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed : 32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed : 32025030). One dimer produces 7 thyroid hormone molecules (PubMed : 32025030). See full target information Thyroglobulin

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