Anti-Thyroglobulin antibody [5F9],Abcam,AB1984

Concentration varies from lot to lot and can be provided on request.

Host

Mouse

Reactivity

Cow, Human

Application

EIA, sELISA

Platform ID

BAB180301443

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Thyroglobulin antibody [5F9]
Cat. No.AB1984
HostMouse
IsotypeIgG2a
ReactivityCow, Human
ApplicationEIA, sELISA
ClonalityMonoclonal
Clone Number5F9
Concentration5.7 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human Thyroglobulin.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.1% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed : 17532758, PubMed : 32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed : 32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed : 32025030). One dimer produces 7 thyroid hormone molecules (PubMed : 32025030). See full target information Thyroglobulin

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