Anti-Tim 2 antibody [RMT2-14],Abcam,AB281909

ab281909 is the recombinant rat version of ab281910 . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rat

Reactivity

Mouse

Application

ICC/IF

Platform ID

BAB931176023

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tim 2 antibody [RMT2-14]
Cat. No.AB281909
HostRat
IsotypeIgG2a
ReactivityMouse
ApplicationICC/IF
ClonalityMonoclonal
Clone NumberRMT2-14
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Protein within Mouse Timd2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Proclin 300 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed : 16203866, PubMed : 33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed : 16043519, PubMed : 21886823). Plays also an important role in the regulation of Th2 immunity (PubMed : 16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed : 12374982). See full target information Timd2

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