Anti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric),Abcam,AB281910

ab281910 is the chimeric rabbit version of ab281909 . This rabbit monoclonal chimeric antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Host

Rabbit

Reactivity

Mouse

Application

ICC/IF

Platform ID

BAB243682270

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tim 2 antibody [RMT2-14] - Rabbit IgG (Chimeric)
Cat. No.AB281910
HostRabbit
IsotypeIgG
ReactivityMouse
ApplicationICC/IF
ClonalityMonoclonal
Clone NumberRMT2-14
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Protein within Mouse Timd2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Proclin 300 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed : 16203866, PubMed : 33065090). Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed : 16043519, PubMed : 21886823). Plays also an important role in the regulation of Th2 immunity (PubMed : 16043519). Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed : 12374982). See full target information Timd2

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