Anti-Tollip antibody,Abcam,AB37155

Host

Rabbit

Reactivity

Rat

Application

WB

Platform ID

BAB372742820

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tollip antibody
Cat. No.AB37155
HostRabbit
IsotypeIgG
ReactivityRat
ApplicationWB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human TOLLIP. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed : 10854325, PubMed : 11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed : 10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed : 11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed : 25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed : 25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed : 15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed : 26320582). See full target information TOLLIP

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