Anti-Transferrin Receptor antibody [EPR20584],Abcam,AB214039
Anti-Transferrin Receptor antibody [EPR20584] (ab214039) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, IP and WB. Anti-Transferrin Receptor antibody [EPR20584] (ab214039) was first used in a scientific publication in 2019 and has been cited over 52 times in peer reviewed journals. It's performance in Western blot in human and mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Transferrin Receptor antibody [EPR20584] (ab214039) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Transferrin Receptor antibody [EPR20584] (ab214039) specifically detects Transferrin Receptor (UniProt ID: P02786; Molecular weight: 85kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR20584 - ab232376 . Antibody clone EPR20584 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488 ( ab317529 ). The transferrin receptor, crucial for cellular iron uptake, is often overexpressed in cancer cells, making it a valuable target for antibody-mediated therapies. Its role in promoting tumor growth and survival highlights its potential as a therapeutic target and a prognostic marker in oncology. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Human, Rat
Application
WB, IP, IHC-P, ICC/IF
Platform ID
BAB187298083
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by the gene TFRC is involved in the cellular uptake of iron via receptor-mediated endocytosis, where the transferrin receptor, bound to its ligand, is internalized into specialized endosomes. Following endosomal acidification, iron is released, and the apotransferrin-receptor complex is recycled to the cell surface, where a return to neutral pH results in the loss of apotransferrin's affinity for its receptor. The hereditary hemochromatosis protein HFE competes with transferrin for binding at an overlapping C-terminal site. TFRC positively regulates T and B cell proliferation through iron uptake. It functions as a lipid sensor influencing mitochondrial fusion by modulating the JNK pathway activity. Low dietary levels of stearate promote JNK pathway activation, leading to HUWE1-mediated ubiquitination and degradation of the mitofusin MFN2, inhibiting mitochondrial fusion. High dietary stearate levels result in TFRC stearoylation, which inhibits JNK pathway activation and MFN2 degradation. Additionally, TFRC acts as a receptor for new-world arenaviruses, including Guanarito, Junin, and Machupo viruses. This supplementary information is collated from multiple sources and compiled automatically. See full target information TFRC
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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