Anti-Twist antibody [Twist2C1a],Abcam,AB50887
What is this antibody validated in? Anti-Twist antibody [Twist2C1a] (ab50887) is a mouse monoclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse, Rat samples. What is the molecular weight of Twist? Anti-Twist [Twist2C1a] (ab50887) specifically detects a band for Twist (UniProt: Q15672) at a molecular weight of 21kDa. Trusted by the scientific community Anti-Twist [Twist2C1a] (ab50887) was first used in a scientific publication in 2007 and has been cited over 240 times in peer-reviewed journals. Reviewed by scientists Anti-Twist [Twist2C1a] (ab50887) has over 25 independent reviews from customers.
Host
Mouse
Reactivity
Mouse, Rat, Human
Application
WB, ICC
Platform ID
BAB942170743
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator : NPAS2-BMAL1 heterodimer (By similarity). See full target information TWIST1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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