Anti-Tyrosinase antibody,Abcam,AB180753

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, WB, IHC-P

Platform ID

BAB629964352

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosinase antibody
Cat. No.AB180753
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, WB, IHC-P
ClonalityPolyclonal
Concentration1.99 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human Tyrosinase aa 1-350. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed : 28661582). See full target information Tyrosinase

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