Anti-Tyrosine Hydroxylase antibody [BLR155J] - BSAfree,Abcam,AB314080

REACH authorisation Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances. It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

Host

Rabbit

Reactivity

Human, Mouse

Application

WB, ICC, IHC-P

Platform ID

BAB442520575

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody [BLR155J] - BSAfree
Cat. No.AB314080
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse
ApplicationWB, ICC, IHC-P
ClonalityMonoclonal
Clone NumberBLR155J
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human TH aa 450-500. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.8 - 8.6 Preservative: 0.09% Sodium azide Constituents: 98% Borate buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed : 15287903, PubMed : 1680128, PubMed : 17391063, PubMed : 24753243, PubMed : 34922205, PubMed : 8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).. Isoform 5. Lacks catalytic activity.. Isoform 6. Lacks catalytic activity. See full target information TH

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