Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker,Abcam,AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P and WB. Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) was first used in a scientific publication in 2016 and has been cited over 69 times in peer reviewed journals. It's performance in Western Blot in mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) has 9 independent reviews from customers. Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869) specifically detects Tyrosine Hydroxylase (UniProt ID: P07101; Molecular weight: 59kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EP1532Y - ab220218 . Antibody clone EP1532Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor ® 488, Alexa Fluor ® 568, Alexa Fluor ® 555, APC, PE, Alexa Fluor ® 647, Alexa Fluor ® 594, Alexa Fluor ® 750 ( ab207673 , ab302827 , ab302968 , ab305365 , ab310825 , ab310901 , ab311092 , ab311693 , ab321111 ). NEW: Explore our alternative host species for clone EP1532Y : goat, mouse, chicken. Tyrosine hydroxylase (TH) is a critical enzyme in neuro research, particularly for its role in the synthesis of catecholamines, including dopamine, norepinephrine and epinephrine. It is a key marker for identifying dopaminergic neurons in the central nervous system. Researchers use tyrosine hydroxylase to study the regulation of neurotransmitter production and its implications in neurological disorders such as Parkinson's disease (PD) and tyrosine hydroxylase deficiency. Its expression helps in understanding the biochemical pathways involved in neurodegenerative diseases and the development of potential therapeutic strategies. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, IHC-P, WB

Platform ID

BAB005051810

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker
Cat. No.AB137869
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, IHC-P, WB
ClonalityMonoclonal
Clone NumberEP1532Y
Concentration0.559 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed : 15287903, PubMed : 1680128, PubMed : 17391063, PubMed : 24753243, PubMed : 34922205, PubMed : 8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).. Isoform 5. Lacks catalytic activity.. Isoform 6. Lacks catalytic activity. See full target information TH

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