Anti-Tyrosine Hydroxylase antibody - Neuronal Marker,Abcam,AB113

ab113 can be used as a marker for dopaminergic and noradrenergic neurons.

Host

Sheep

Reactivity

Rat

Application

WB

Platform ID

BAB192595539

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody - Neuronal Marker
Cat. No.AB113
HostSheep
IsotypeIgG
ReactivityRat
ApplicationWB
ClonalityPolyclonal
Concentration0.15 - 1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Rat TH.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed : 10933781, PubMed : 11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). See full target information TH

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