Anti-Tyrosine Hydroxylase antibody - Neuronal Marker,Abcam,AB137721

Host

Rabbit

Reactivity

Mouse, Rat, Human, Zebrafish

Application

ICC/IF, IHC-Fr, WB, IHC-P

Platform ID

BAB505101786

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody - Neuronal Marker
Cat. No.AB137721
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human, Zebrafish
ApplicationICC/IF, IHC-Fr, WB, IHC-P
ClonalityPolyclonal
Concentration0.43 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TH aa 150-500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed : 15287903, PubMed : 1680128, PubMed : 17391063, PubMed : 24753243, PubMed : 34922205, PubMed : 8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).. Isoform 5. Lacks catalytic activity.. Isoform 6. Lacks catalytic activity. See full target information TH

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