Anti-Tyrosine Hydroxylase antibody - Neuronal Marker,Abcam,AB112

Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab112) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB. Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab112) has been cited over 389 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab112) has high sensitivity and specificity. Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab112) has 37 independent reviews from customers. Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab112) specifically detects Tyrosine Hydroxylase (UniProt ID: P04177; Molecular weight: 56kDa) and is sold in 100 µL selling sizes. ab112 can be used as a marker for dopaminergic and noradrenergic neurons.

Host

Rabbit

Reactivity

Rat

Application

IHC-P, WB

Platform ID

BAB880089292

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody - Neuronal Marker
Cat. No.AB112
HostRabbit
IsotypeIgG
ReactivityRat
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration0.1 - 1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Rat TH.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed : 10933781, PubMed : 11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). See full target information TH

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