Anti-Tyrosine Hydroxylase antibody [TOH A1.1] - Neuronal Marker,Abcam,AB150659

ab150659 reacts with tyrosine hydroxylase immunoreactive sites in the known catecholaminergic neurons and and fibre systems of rat brain. It recognizes best the configuration of tyrosine hydroxylase in fixed tissues.

Host

Mouse

Reactivity

Rat

Application

IHC-Fr, EM, ICC/IF

Platform ID

BAB067633021

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Tyrosine Hydroxylase antibody [TOH A1.1] - Neuronal Marker
Cat. No.AB150659
HostMouse
IsotypeIgG1
ReactivityRat
ApplicationIHC-Fr, EM, ICC/IF
ClonalityMonoclonal
Clone NumberTOH A1.1
Concentration1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Rat TH.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationConstituents: 99% Water
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed : 10933781, PubMed : 11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). See full target information TH

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