Anti-U1-C antibody [4H12],Abcam,AB122901

Host

Rat

Reactivity

Mouse, Human

Application

IP, ICC/IF, WB

Platform ID

BAB380239220

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-U1-C antibody [4H12]
Cat. No.AB122901
HostRat
IsotypeIgG2a
ReactivityMouse, Human
ApplicationIP, ICC/IF, WB
ClonalityMonoclonal
Clone Number4H12
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Mouse Snrpc.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6 - 8.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. See full target information Snrpc

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