Anti-UCP1 antibody [EPR23004-34],Abcam,AB234430

What is this antibody validated in? Anti-UCP1 antibody [EPR23004-34] (ab234430) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Mouse, Rat samples. What is the molecular weight of UCP1? Anti-UCP1 [EPR23004-34] (ab234430) specifically detects a band for UCP1 (UniProt: P12242) at a molecular weight of 33kDa. Trusted by the scientific community Anti-UCP1 [EPR23004-34] (ab234430) was first used in a scientific publication in 2019 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-UCP1 antibody [EPR23004-34] (ab234430) has been confirmed by Western blot testing in Ucp1 Knockout Mouse brown fat samples. Other related products We have a range of other formats of antibody clone [EPR23004-34] also available for your convenience: ab234430, Carrier free - ab261912 , Alexa Fluor® 488 - ab311016 , Alexa Fluor® 647 - ab311143 , Alexa Fluor® 594 - ab311782 , Alexa Fluor® 568 - ab313063 , Alexa Fluor® 555 - ab313263 , Alexa Fluor® 750 - ab321477 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat

Application

WB, IP, IHC-Fr, IHC-P

Platform ID

BAB319157289

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-UCP1 antibody [EPR23004-34]
Cat. No.AB234430
HostRabbit
IsotypeIgG
ReactivityMouse, Rat
ApplicationWB, IP, IHC-Fr, IHC-P
ClonalityMonoclonal
Clone NumberEPR23004-34
Concentration0.532 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP (PubMed : 23063128). Responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (PubMed : 19187776, PubMed : 23063128, PubMed : 27027295, PubMed : 9139827). Regulates the production of reactive oxygen species/ROS by mitochondria (PubMed : 20416274, PubMed : 20466728). See full target information Ucp1

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