Anti-UCP3 antibody [mAbcam61299],Abcam,AB61299

Target data Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed : 21775425, PubMed : 36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed : 11171965, PubMed : 12670931, PubMed : 12734183, PubMed : 9305858). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed : 11707458). See full target information UCP3