Anti-USP30 antibody [CL4438],Abcam,AB219969

Host

Mouse

Reactivity

Human

Application

IHC-P, WB

Platform ID

BAB883687564

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-USP30 antibody [CL4438]
Cat. No.AB219969
HostMouse
IsotypeIgG2a
ReactivityHuman
ApplicationIHC-P, WB
ClonalityMonoclonal
Clone NumberCL4438
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human USP30 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN) : hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed : 18287522, PubMed : 24896179, PubMed : 25527291, PubMed : 25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed : 25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed : 25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). See full target information USP30

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