Anti-USP35 antibody,Abcam,AB254939

Target data Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed : 26348204, PubMed : 29449677, PubMed : 37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed : 26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed : 29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed : 34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed : 25915564). See full target information USP35