Anti-VEGFA antibody,Abcam,AB46154

New batches of this antibody are no longer guaranteed in ICC/IF, IHC-P or IHC-Fr as they have not passed our stringent batch testing criteria. Please contact customer support for any specific queries. We recommend ab52917 as an alternative for ICC/IF and IHC-P. Product Specifications Anti-VEGFA antibody (ab46154) is a rabbit polyclonal antibody and is validated for use in ELISA, WB in human, mouse samples. Anti-VEGFA antibody (ab46154) specifically detects VEGFA (UniProt ID: P15692; Molecular weight: 44kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-VEGFA antibody (ab46154) has high sensitivity and specificity. Anti-VEGFA antibody (ab46154) has been cited over 714 times in peer reviewed journals and is trusted by the scientific community. Anti-VEGFA antibody (ab46154) has 28 independent reviews from customers.

Host

Rabbit

Reactivity

Mouse, Human

Application

WB, ELISA

Platform ID

BAB198292803

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-VEGFA antibody
Cat. No.AB46154
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationWB, ELISA
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data N-VEGF. Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed : 35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity).. VEGFA. Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth (PubMed : 34530889). Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed : 17446437).. Isoform VEGF165B. Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. See full target information VEGFA

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