Anti-VGluT1 antibody [N28-9] - BSA and Azide free,Abcam,AB264108
ab264108 is the carrier-free version of ab134283 . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected] Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Mouse
Reactivity
Mouse, Rat, Human
Application
WB, IHC-P
Platform ID
BAB636261328
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed : 10938000, PubMed : 11001057, PubMed : 11698619, PubMed : 18080752, PubMed : 19169251, PubMed : 25433636, PubMed : 27133463, PubMed : 29642010, PubMed : 33440152, PubMed : 8202535). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed : 10938000, PubMed : 11001057, PubMed : 11698619, PubMed : 18080752, PubMed : 29642010). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed : 29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed : 10938000, PubMed : 19169251, PubMed : 25433636, PubMed : 27133463, PubMed : 29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed : 25433636). The vesicular K(+)/H(+) antiport activity is electroneutral (PubMed : 25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed : 29642010, PubMed : 33440152, PubMed : 8202535). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed : 29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). See full target information Slc17a7
Category Paths
- Products>Primary Antibodies>IHC Antibodies
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