Anti-WAC antibody,Abcam,AB109486

Target data Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed : 21329877). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed : 21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed : 21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed : 22354037). Also acts as a negative regulator of basal autophagy (PubMed : 26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed : 26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed : 21329877). See full target information WAC