Anti-ZBTB48 antibody - N-terminal,Abcam,AB225935

Target data Telomere-binding protein that acts as a regulator of telomere length (PubMed : 28082411, PubMed : 28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed : 28082411, PubMed : 28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed : 28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed : 24382891, PubMed : 28500257, PubMed : 7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed : 28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed : 7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed : 24382891). See full target information ZBTB48