Anti-ZMYND8 antibody [EPR16924],Abcam,AB201452

Target data Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) (PubMed : 26655721, PubMed : 27477906, PubMed : 31965980, PubMed : 36064715). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac (PubMed : 27477906). May also act as a transcriptional corepressor for KDM5C and EZH2 (PubMed : 33323928). Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination (PubMed : 25593309, PubMed : 27732854, PubMed : 30134174). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (PubMed : 26655721, PubMed : 30134174). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression (PubMed : 26655721). Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform (PubMed : 30134174, PubMed : 35916866, PubMed : 36064715). Suppresses breast cancer, and prostate cancer cell invasion and metastasis (PubMed : 27477906, PubMed : 31965980, PubMed : 33323928). See full target information ZMYND8