Anti-Zinc finger antiviral protein antibody,Abcam,AB154680

Target data Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae, including human immunodeficiency virus type 1, filoviridae : ebola virus (EBOV) and marburg virus (MARV), togaviridae : sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation.. Isoform 1. Exhibits stronger antiviral activity than isoform 2 against MuLV expression and Semliki forest virus infection (PubMed : 18225958). Increased antiviral activity may be due to more efficient targeting to endocytic membranes through S-farnesylation (By similarity). Similarly to isoform 2, prevents HIV-1 infection (PubMed : 21876179).. Isoform 2. Positive regulator of RIGI signaling during the innate antiviral immune response. Associates with RIGI to promote its oligomerization and ATPase activity stimulation, leading to robust activation of IRF3 and NF-kappa-B transcription factors and eventually to the expression of type I IFNs and IFN stimulated genes (ISGs) (PubMed : 21102435). Similarly to isoform 1, prevents HIV-1 infection (PubMed : 21876179). See full target information ZC3HAV1