Anti-alpha 1 Antitrypsin antibody [TMF1 4B5],Abcam,AB116604

Host

Mouse

Reactivity

Mouse, Human

Application

RIA, ELISA, IP

Platform ID

BAB386992299

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-alpha 1 Antitrypsin antibody [TMF1 4B5]
Cat. No.AB116604
HostMouse
IsotypeIgG2a
ReactivityMouse, Human
ApplicationRIA, ELISA, IP
ClonalityMonoclonal
Clone NumberTMF1 4B5
Concentration1 mg/mL Batch dependent concentration
ImmunogenNative Full Length Protein corresponding to Human SERPINA1.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.. Short peptide from AAT. Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). See full target information SERPINA1

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