Anti-beta III Tubulin antibody [2G10] - Neuronal Marker,Abcam,AB78078
Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) is a mouse monoclonal antibody and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP and WB. Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) was first used in a scientific publication in 1990 and has been cited over 323 times in peer reviewed journals. It's performance in Western blot and IHC in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) has high sensitivity and specificity. The specificity of Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) has been confirmed by WB testing in beta III Tubulin knockout HAP1 cells. Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) has 40 independent reviews from customers. Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (ab78078) specifically detects beta III Tubulin (UniProt ID: Q4QRB4; Molecular weight: 51kDa) and is sold in 100 ug selling sizes. Conjugation-ready, carrier free format available for antibody clone 2G10 - ab264097 . Antibody clone 2G10 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, HRP ( ab195879 , ab19588 , ab196638 ). TUBB3, also known as beta-III tubulin, is a critical protein in neuro research, particularly for its role as a marker of neuronal differentiation and axonal growth. It is predominantly expressed in neurons and is essential for proper microtubule function and stability. Researchers use TUBB3 to study neuronal development, neurogenesis and the structural integrity of neurons, making it vital for understanding various neurodevelopmental and neurodegenerative conditions. Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]
Host
Mouse
Reactivity
Dogfish, Common marmoset, Catshark, Mouse, Rat, Human
Application
Flow Cyt (Intra), WB, IP, IHC-P, ICC/IF
Platform ID
BAB600123740
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity). See full target information Tubb3
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