Anti-beta III Tubulin antibody - Neuronal Marker,Abcam,AB18207
Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) is a rabbit polyclonal antibody and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, WB. Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) has been cited over 627 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) has high sensitivity and specificity. The specificity of Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) has been confirmed by testing in knockout samples. Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) has 67 independent reviews from customers. beta III Tubulin antibodies are often used as loading controls in Western Blot. Anti-beta III Tubulin antibody - Neuronal Marker has been verified in Western Blot samples and detects a band at 50kDa Molecular weight. Anti-beta III Tubulin antibody - Neuronal Marker (ab18207) specifically detects beta III Tubulin (UniProt ID: Q13509; Molecular weight: 50kDa) and is sold in 100 µg selling sizes. Beta-tubulin III (TUBB3) is a protein that is predominantly expressed in neurons and is a critical component of the microtubule network. It plays a vital role in maintaining the structure and function of neurons. It is a key marker for neurons and is involved in processes such as axon guidance and neuronal differentiation. Abnormal expression of TUBB3 has been associated with several neurological conditions, including congenital fibrosis of the extraocular muscles (CFEOM) and cortical dysplasia, complex with other brain malformations (CDCBM), underscoring its critical role in brain development. Browse our curated portfolio of extensively validated antibodies and assays, with antibodies to over 90% of key targets in major glioblastoma pathways– including EGF, VEGF, MAPK, Wnt, NFKB, and PI3K/AkT/MTOR – all in one place.
Host
Rabbit
Reactivity
Mouse, Rat, Human, Common marmoset, Dogfish, Catshark
Application
WB, IHC-P, ICC/IF, Flow Cyt (Intra)
Platform ID
BAB975211198

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed : 34996871, PubMed : 38305685, PubMed : 38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed : 34996871, PubMed : 38305685, PubMed : 38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed : 34996871, PubMed : 38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed : 20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed : 28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed : 28483977). See full target information TUBB3
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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