Anti-c-Fos antibody [EPR21930-238],Abcam,AB222699
Product Specifications Anti-c-Fos antibody [EPR21930-238] (ab222699) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse samples. Anti-c-Fos antibody [EPR21930-238] (ab222699) specifically detects c-Fos (UniProt ID: P01100; Molecular weight: 41kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-c-Fos antibody [EPR21930-238] (ab222699) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-c-Fos antibody [EPR21930-238] (ab222699) has been cited over 42 times in peer reviewed journals and is trusted by the scientific community. Anti-c-Fos antibody [EPR21930-238] (ab222699) has 6 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR21930-238 - ab234964 . Antibody clone EPR21930-238 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 488 ( ab300747 , ab302541 , ab302685 , ab303464 , ab306605 ). Target Information c-Fos is an immediate-early gene widely used in neuro research for its role as a marker of neuronal activation. It is rapidly expressed in response to various stimuli, making it an excellent indicator of neuronal activity and functional mapping. Researchers use c-Fos to study brain activity patterns, synaptic plasticity, and the effects of drugs or other interventions on the central nervous system, making it essential for understanding dynamic changes in brain function. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Human
Application
ICC/IF, Flow Cyt (Intra), WB, IP, IHC-P
Platform ID
BAB108369780
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. See full target information FOS
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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