Anti-c-Jun antibody [E254] - ChIP Grade,Abcam,AB32137
What is this antibody validated in? Anti-c-Jun antibody [E254] - ChIP Grade (ab32137) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), ChIP in Human, Mouse, Rat samples. What is the molecular weight of c-Jun? Anti-c-Jun [E254] - ChIP Grade (ab32137) specifically detects a band for c-Jun (UniProt: P05412) at a molecular weight of 36kDa. Trusted by the scientific community Anti-c-Jun [E254] - ChIP Grade (ab32137) was first used in a scientific publication in 2006 and has been cited over 100 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [E254] also available for your convenience: ab32137, HRP - ab193782 , Carrier free - ab218576 , Alexa Fluor® 488 - ab310946 , Alexa Fluor® 647 - ab311064 , Alexa Fluor® 594 - ab311649 , Alexa Fluor® 568 - ab312922 , Alexa Fluor® 555 - ab313134 , Alexa Fluor® 750 - ab321580 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ChIP, WB, IP, IHC-P
Platform ID
BAB358494720
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed : 10995748, PubMed : 22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed : 12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed : 17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed : 24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed : 24623306).. (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. See full target information JUN
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