Anti-c-Kit antibody [YR145],Abcam,AB32363
What is this antibody validated in? Anti-c-Kit antibody [YR145] (ab32363) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Common marmoset, Human samples. What is the molecular weight of c-Kit? Anti-c-Kit [YR145] (ab32363) specifically detects a band for c-Kit (UniProt: P10721) at a molecular weight of 110kDa. Trusted by the scientific community Anti-c-Kit [YR145] (ab32363) was first used in a scientific publication in 2006 and has been cited over 60 times in peer-reviewed journals. Reviewed by scientists Anti-c-Kit [YR145] (ab32363) has over 10 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-c-Kit antibody [YR145] (ab32363) has been confirmed by Western blot testing in KIT Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [YR145] also available for your convenience: ab32363, Carrier free - ab216450 , Alexa Fluor® 488 - ab309968 , Alexa Fluor® 647 - ab311175 , Alexa Fluor® 594 - ab311830 , Alexa Fluor® 568 - ab313113 , Alexa Fluor® 555 - ab313306 , Alexa Fluor® 750 - ab321591 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human, Common marmoset
Application
WB, IHC-P
Platform ID
BAB171250847
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. See full target information KIT
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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